One is an inactivated (killed) vaccine and the other is a live, attenuated (weakened) vaccine. There are two vaccines to prevent typhoid fever. Typhoid fever is not common in the United States. Typhoid fever is common in many regions of the world, including parts of East and Southeast Asia, Africa, the Caribbean, and Central and South America. There are fewer antibiotic treatment options as drug-resistant typhoid bacteria has become more common in many parts of the world. As many as 30% of people who do not get treatment die from complications of typhoid fever. People who do not get treatment can continue to have fever for weeks or months. Symptoms of infection include persistent high fever, weakness, stomach pain, headache, diarrhea or constipation, cough, and loss of appetite. Typhoid fever can be a life-threatening disease. When someone eats or drinks contaminated food or drink, the bacteria can multiply and spread into the bloodstream, causing typhoid fever. People who are actively ill with typhoid fever and people who are carriers of the bacteria that cause typhoid fever can both spread the bacteria to other people. Typhoid vaccine can prevent typhoid fever.
